Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective
نویسندگان
چکیده
منابع مشابه
Current strategies towards therapeutic manipulation of mtDNA heteroplasmy.
Mitochondrial disease is a multifactorial disorder involving both nuclear and mitochondrial genomes. Over the past 20 years, great progress was achieved in the field of gene editing which raised the possibility of partial or complete elimination of mutant mtDNA that causes disease phenotypes. Each cell contains thousands of copies of mtDNA which can be either wild-type (WT) or mutant, a conditi...
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Functional variability among human clones of induced pluripotent stem cells (hiPSCs) remains a limitation in assembling high-quality biorepositories. Beyond inter-person variability, the root cause of intra-person variability remains unknown. Mitochondria guide the required transition from oxidative to glycolytic metabolism in nuclear reprogramming. Moreover, mitochondria have their own genome ...
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Heteroplasmy, the presence of more than one type of mtDNA within cells, is common in animals and has been associated with aging and disease in humans. Changes in the frequencies of mtDNA variants between cell and animal generations thus bears on the evolution of mtDNA and the progression of diverse pathologies. We have used densitometry of Southern blots of individual heteroplasmic Drosophila m...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2020
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2020.02.006